Abstract:Tic disorder is a common neurodevelopmental disease in childhood, which is mainly manifested as involuntary repetition, sudden movement and / or phonation, and may be accompanied by attention deficit hyperactivity disorder, learning disorder, obsessive-compulsive disorder, conduct disorder, etc., seriously affecting the children’ s learning, social adaptability and psychological healthy development. However, its etiology, pathogenesis and pharmacological mechanism have not been fully clarified, and these basic studies need to be further explored and verified through animal models. At present, there are a variety of construction method of tic disorder models, mainly based on the possible pathogenesis of the disease, such as neurotransmitter abnormalities, immune dysfunction, genetic factors, etc., but there is no animal model that can completely meet the manifestations of tic disorder. This paper summarizes the commonly used animal models of tic disorder, in order to provide a reference for experimental studies.