Effects of taurine on growth axis hormones and genes in pregnant rats with intrauterine growth restriction
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1.College of Veterinary and Animal Science, Shenyang Agricuhural University, Shenyang Liaoning 110866, China. 2. Liaoning He’s Medical College, Shenyang 110163

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    Abstract:

    Objective To observe the effects of taurine on blood hormones and hepatic insulin growth factor (IGF) gene expression in intrauterine growth-restricted pregnant rats. Methods Healthy SD female and male rats were housed 1 ∶2 in cages and pregnant rats were randomly selected into the blank control group (C), model group (M), model + taurine group (MT), and taurine group (T). In the M and MT groups, 10 pregnant rats were fed a low-protein diet. Day 12 of pregnancy, C, and M were provided drinking water, and MT and T groups received taurine 300 mg / (kg·d). Weekly monitoring of weight gain in pregnant rats. At day 21 of gestation, baseline characteristics of fetuses were determined. Serum growth hormone (GH), insulin growth factor 1 (IGF-1), insulin (INS), and thyroxine (T3 and T4) levels were detected by ELISA. Fluorescent quantitative PCR was used to detect the hepatic expression levels of growth hormone receptor (GHR), insulin growth factoR-1 ( IGF-1), insulin growth factor binding protein-1 ( IGFBP-1) and insulin growth factor binding protein-3 ( IGFP-3) mRNA in pregnant rats. Results Taurine markedly improved the baseline characteristics, compared with the M group. Pregnant rats in the MT group had significantly increased (P < 0. 05) weights, blood INS and T4 levels, and liver IGF-1 and IGFBP-3 mRNA expression, whereas IGFBP-1 mRNA expression was significantly reduced (P < 0. 01). Conclusions The addition of taurine can improve the thyroid function and GH/ IGF-1 axis disorder in low- protein diet pregnant rats, and may play an important role in alleviating fetal growth restriction.

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History
  • Received:October 27,2019
  • Revised:
  • Adopted:
  • Online: July 03,2020
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