Anti-atherosclerotic and cardioprotective effects of perilla seed extract on ApoE -/ - mice
Received:June 19, 2019  
View Full Text  View/Add Comment  Download reader
DOI:10. 3969 / j.issn.1005-4847. 2019. 06. 001
KeyWord:perilla seed extract; ApoE -/ - mice; atherosclerosis; cardioprotection
郑双 1. 广东药科大学,生命科学与生物制药学院,血管生物学研究所,广州 ;2. 广东省实验动物监测所,广东省实验动物重点实验室,广州
谭伟江 广东省实验动物监测所,广东省实验动物重点实验室,广州
李想 广东省实验动物监测所,广东省实验动物重点实验室,广州
马俊峰 广东省实验动物监测所,广东省实验动物重点实验室,广州
任学聪 广东省实验动物监测所,广东省实验动物重点实验室,广州
郑凌云 广东药科大学,生命科学与生物制药学院,血管生物学研究所,广州
王丽京 广东药科大学,生命科学与生物制药学院,血管生物学研究所,广州
杨丰华 广东省实验动物监测所,广东省实验动物重点实验室,广州
黄韧 1. 广东药科大学,生命科学与生物制药学院,血管生物学研究所,广州 ;2. 广东省实验动物监测所,广东省实验动物重点实验室,广州
Hits: 1228
Download times: 506
      Objective To study the role and molecular mechanism of perilla seed oil extract (PSO) in reducing arterial plaque formation and providing cardioprotection in ApoE -/ - mice. Methods Three-month-old ApoE -/ - mice were randomly divided into ApoE -/ -(no drug treatment), low-dose PSO, high-dose PSO and atorvastatin groups. B6 mice of the same age were used as controls (WT group); they were fed a regular diet. After 8 weeks of treatment, biochemical tests, H&E staining, echocardiography, qPCR, ATP detection and Pro-Q Diamond staining were performed. Results Compared with the WT group, ApoE -/ - mice showed abnormal cardiac structure and function. After PSO treatment, the plaque area was reduced, and cardiac structure and function improved. mRNA expression of ANP, BNP and β-MHC was downregulated, mRNA expression of PPARα and PGC-1α was up-regulated, and the intracellular content of ATP and the phosphorylation level of TnI were increased. Conclusions PSO inhibits arterial plaque formation and maintains normal cardiac structure and function in ApoE -/ - mice. It may regulate the PPARα/ PCG-1α/ NRF-1 axis to increase ATP and myofilament phosphorylation, improve energy metabolism, and exert cardioprotective action.
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes";,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h;,"",win); } &et=183A397792899D275B679C9FDA819CE108184C894E0C09BBA39F2BC7D938BD1659A300DB1B8A65A6628B5E18D348BDAD71A14AB972E4542CB32E4984AAA2D6A503D0097EEEA53285727B36517FFE25100099117D6D44D3AD4F580BD53F3F894748896BA71A480E81&pcid=&cid=&jid=&yid=B6351343F4791CA3&aid=&vid=&iid=B31275AF3241DB2D&sid=21A4BC96BDC43D33&eid=09F7C8D609E885AE&fileno=201906001&flag=1&is_more=0"> var my_pcid=""; var my_cid=""; var my_jid=""; var my_yid="B6351343F4791CA3"; var my_aid="";