Progress in research on animal models of colorectal cancer with liver metastasis generated by patient-derived tumor xenograft
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(1. Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu, China.2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu)

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Q95-33

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    Abstract:

    Liver is the main target organ for colorectal cancer metastasis. Liver metastasis is also the main cause of death in patients with colorectal cancer. Recent studies have shown that liver metastasis of colorectal cancer patient-derived tumor xenograft (PDTX) can better replicate the clinical characteristics of clinical tumors colon cancer. At present, the primary models used are the orthotopic tumor xenograft model and ectopic tumor xenograft model. To provide a reference for experimental modeling, this paper reviews PDTX animal models for colorectal cancer liver metastasis and their application range.

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History
  • Received:December 25,2018
  • Revised:
  • Adopted:
  • Online: September 04,2019
  • Published: