Effects of heroin on embryonic development and Bax expression in embryonic rat brain tissue
Received:February 26, 2019  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 04. 016
KeyWord:heroin; embryonic development; Bax expression; rat
俞发荣 甘肃省证据科学技术研究与应用重点实验室甘肃政法大学,兰州 
李建军 甘肃省证据科学技术研究与应用重点实验室甘肃政法大学,兰州 
连秀珍 甘肃省证据科学技术研究与应用重点实验室甘肃政法大学,兰州 
李登楼 甘肃省证据科学技术研究与应用重点实验室甘肃政法大学,兰州 
谢明仁 甘肃省证据科学技术研究与应用重点实验室甘肃政法大学,兰州 
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      Objective To study the effects of heroin on the development and brain Bax expression in embryonicrat brain tissues. Methods Wistar rats were randomly divided into a control group or heroin administration groups (low,medium, and high dose groups). On the 7th day, 16, 32, and 64 mg/ kg of heroin were administered to the low, medium,and high dose groups, respectively, and heroin was continuously administered for 9 days. The effects of heroin onmorphological development of embryonic rats were measured, and the expression levels of Bax in embryonic brain tissueswas detected using enzyme-linked immunosorbent assay (ELISA). Results The total numbers of living embryos in thelow, medium, and high dose heroin groups were decreased by 27. 27%, 37. 12%, and 48. 48%, respectively, comparedwith the control group ( P < 0. 01). Bax expression levels in embryonic cerebral tissues of the low, medium, and high doseheroin groups were increased by 11. 41%, 47. 06%, and 83. 74%, respectively, compared with the control group ( P <0. 05; P < 0. 01). Bax expression levels in the embryonic cerebellar tissue were increased by 17. 16%, 52. 96%, and90. 01%, respectively, compared with the control group ( P < 0. 05; P < 0. 01). Conclusions  Heroin inhibitsmorphological development in embryonic rats, and this inhibitory effect increases with increasing doses of heroin. This effectmay be caused by the heroin-induced upregulation of Bax expression in embryonic tissues and organs.
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