Recent advances in understanding of quantitative trait loci and pathogenic genes associated with canine hip dysplasia
Received:December 18, 2018  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 03. 021
KeyWord:canine hip dysplasia; quantitative trait locus; candidate causative genes
                 
AuthorInstitution
肖启程 四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,成都
彭广能 四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,成都
刘海峰 四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,成都
周紫峣 四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,成都
马晓平 四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,成都
钟志军 四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,成都
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Abstract:
      Canine hip dysplasia (CHD) is a common congenital hereditary disease characterized predominantly byhip joint relaxation. While both environmental and genetic factors are known to contribute to the disease, the underlyingmechanism of pathogenesis remains unknown. In recent years, significant progress has been achieved in the genomics ofCHD. For example, a quantitative trait locus (QTL) was identified for CHD that is associated with the Norberg angle of thehip joint, the dorsolateral subluxation score and the separation index. In addition, genes such as FBN2, LRR1, COL6A3and FN1 have been shown to be associated with CHD. In this review, we summarize current research in this field, withparticular focus on the chromosomal position of the identified QLT and the known functions of candidate disease-causing genes associated with CHD.
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