Research progress of the 6 Hz corneal kindling seizure animal models
Received:December 18, 2018  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 03. 019
KeyWord:epilepsy; 6 Hz; corneal kindling; animal model
高青 1. 中南大学湘雅医院临床药理研究所,长沙 ; 2. 中南大学临床药理研究所,遗传药理学湖南省重点实验室,长沙
曾贵荣 1. 北京协和医学院药用植物研究所,北京 ;2. 湖南省药物安全评价研究中心/ 新药药效与安全评价湖南省重点实验室,长沙
欧阳冬生 1. 中南大学湘雅医院临床药理研究所,长沙 ; 2. 中南大学临床药理研究所,遗传药理学湖南省重点实验室,长沙 ; 3. 复杂基质样本生物分析湖南省重点实验室,长沙
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      Drug resistance is a major problem in the prevention and treatment of epilepsy. Animal models ofepilepsy are powerful tools to study the mechanism of epilepsy, screening antiepileptic drugs, and explore the mechanismsof drug actions. The 6 Hz corneal kindling seizure model is an excellent animal model of drug-resistant epilepsy, which isrecommended by the NIH as a screening tool to evaluate new drugs against drug-resistant epilepsy. However, there iscurrently no systematic report of this model. Here, we review the development history, production method, symptoms,pathogenesis, and application status of the model to provide a reference to explore the pathogenesis of drug-resistant epilepsy and screening drugs for the treatment of drug-resistant epilepsy.
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