Current status of research on animal models of intervertebral disc degeneration
Received:January 11, 2019  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 03. 016
KeyWord:intervertebral disc degeneration; nucleus pulposus; annulus fibrosus; animal model; gene knockout
海宝 北京大学第三医院骨科, 北京
祝斌 北京大学第三医院疼痛医学中心, 北京
刘晓光 1. 北京大学第三医院骨科, 北京 ; 2. 北京大学第三医院疼痛医学中心, 北京
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      Degeneration of intervertebral discs is a major cause of lower back pain that seriously affects quality oflife and productivity. Although the specific pathogenesis is still unclear, recent research of related animal models has madegreat progress. The modeling method include structural damage, stress changes, and gene knockout. In this review, wefocus on the advantages and disadvantages of these Methods and their applications to establish a theoretical foundation for subsequent research.
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