Research progress in establishment and application of mouse models of leukemia
Received:July 15, 2018  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 02. 022
KeyWord:acute leukemia; mouse; model
马畅 1. 广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 ; 2. 河南大学药学院,河南开封 ; 3. 广东莱恩医药研究院有限公司重点实验室,广州
郭健敏 1. 广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 ; 2. 广东莱恩医药研究院有限公司重点实验室,广州
谢松强 河南大学药学院,河南开封
杨威 1. 广东省生物资源应用研究所,广东省动物保护与资源利用重点实验室,广东省野生动物保护与利用公共实验室,广州 ; 2. 广东莱恩医药研究院有限公司重点实验室,广州
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      Leukemia is often referred to as a “blood cancer”. The basic characteristic of the disease is thatleukemic cells become malignant and cause unrestricted proliferation in the bone marrow and other hematopoietic tissues.Then, these cells infiltrate all tissues and organs of the body causing various symptoms, and make patients prone to seriousinfections and life-threatening complications such as sepsis, hemorrhage, intestinal failure or hyperuricemia. Therefore,research on the treatment of leukemia using laboratory animal models is of great significance. For the study of leukemia,mice are similar to humans in terms of biology, genetics, and hematopoietic systems, and are, therefore, ideal models forleukemia research. This article reviews the mouse models of leukemia used commonly in studies both in China and abroad in the past 5 years.
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