Research progress of ferret models of influenza A virus infection
Received:September 28, 2018  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 02. 020
KeyWord:influenza A virus; ferret; animal model; pathogenesis; transmission; vaccine development
马树杰 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室, 哈尔滨
张博 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室, 哈尔滨
孔宇飞 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室, 哈尔滨
关云涛 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室, 哈尔滨
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      Influenza A viruses (IAVs) infect humans and animals, and pose continuous threats to public health.Animal models have pivotal roles in IAV research, and different animal models have different advantages and limitations.We focused on the advantages and disadvantages of the use of ferrets, and compared them with those of mice, guinea pigs,and non-human primate models. We highlighted the important role of ferrets in IAV research. This paper briefly reviews theresearch progress in use of ferret models in the studies of pathogenesis, transmission and evaluation of IAVs. As such, it provides references for the basic and applied research of IAVs.
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