Molecular nature of dorsal-ventral patterning in the zebrafish embryo
Received:January 13, 2019  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 02. 018
KeyWord:dorsal-ventral patterning; Wnt signaling; BMP signaling; zebrafish
闫一芳 1. 中国科学院动物研究所,膜生物学国家重点实验室,北京 ;2. 中国科学院大学,存济医学院,北京
王强 1. 中国科学院动物研究所,膜生物学国家重点实验室,北京 ;2. 中国科学院大学,存济医学院,北京
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      Vertebrate development begins with the patterning of the body axis, which is one of the most significantevents during early embryonic development. Previous genetic evidences suggest that Wnt, bone morphogenic protein(BMP), Nodal, and fibroblast growth factor (FGF) signaling networks act together to control the complex morphogeneticcell movements, development of the three germ layers, and establishment of dorsal-ventral, anterior-posterior, and left-rightaxes. In this review, we focus on the molecular nature of dorsal-ventral patterning in the zebrafish embryo, including a briefintroduction of the dorsal organizer, the molecular mechanisms of the Wnt/ β-catenin signaling pathway in dorsal organizerformation, and the molecular mechanisms of BMP signaling in establishment of the dorsal-ventral axis. Finally, we discuss the future directions of dorsal-ventral patterning research.
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