Research progress of animal models of myocardial injury induced by isoproterenol
Received:September 02, 2018  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 01. 018
KeyWord:isoproterenol; myocardial injury; pathogenesis
梁娟 哈尔滨医科大学附属第一医院,哈尔滨 
刘越 哈尔滨医科大学附属第一医院心内科,哈尔滨 
尹新华 哈尔滨医科大学附属第一医院心内科,哈尔滨 
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      Cardiovascular disease (CVD) is a leading cause of human death worldwide, but its pathogenesis and prevention still need further research. Isoproterenol (ISO) is a β-adrenergic receptor agonist that acts directly or indirectly on the myocardium through inflammatory responses, oxidative stress, endoplasmic reticulum stress, autophagy, and apoptosis, which can cause mild myocardial injury, myocardial infarction, cardiac hypertrophy, and even heart failure. This review mainly focuses on the research on animal models of myocardial injury caused by ISO and attempts to describe its morphological and functional characteristics, as well as its pathogenesis.
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