Antidepressant effects of cajaninstilbene acid on chronic unpredictable mild stress-induced depressive mice
Received:August 27, 2018  
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DOI:10. 3969 / j.issn.1005-4847. 2019. 01. 014
KeyWord:cajaninstilbene acid; antidepressant; chronic unpredictable mild stress; corticosterone;neurotransmitters; mouse
                       
AuthorInstitution
张梦荻 中国医学科学院北京协和医学院药用植物研究所,北京 
王丽莎 中国医学科学院北京协和医学院药用植物研究所,北京 
李晨晨 中国医学科学院北京协和医学院药用植物研究所,北京 
陶雪 中国医学科学院北京协和医学院药用植物研究所,北京 
周云丰 中国医学科学院北京协和医学院药用植物研究所,北京 
刘新民 1. 中国医学科学院北京协和医学院药用植物研究所,北京 ; 2. 中国航天员科研训练中心人因工程重点实验室,北京 
潘瑞乐 中国医学科学院北京协和医学院药用植物研究所,北京 
常琪 中国医学科学院北京协和医学院药用植物研究所,北京 
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Abstract:
      Objective Cajaninstilbene acid comprises a relatively high proportion of the stilbene in pigeon pea leaves and has significant anti-inflammatory and neuroprotective effects. This study aimed to observe the antidepressant effect of cajaninstilbene acid and explore its possible mechanism. Methods A mouse model of depression was established by chronic unpredictable mild stress (CUMS) and were treated with cajaninstilbene acid. A sucrose preference test was used to evaluate the degree of anhedonia and the serum corticosterone level was detected by ELISA. The concentrations of several neurotransmitters in the cortex and hippocampus were determined by LC-MS/ MS. Results Cajaninstilbene acid reversed the decreased sucrose preference and the increased serum corticosterone levels induced by CUMS. Compared with the control group, the levels of several neurotransmitters were significantly changed in the cortex and hippocampus of CUMS mice, regulated by cajaninstilbene acid. Conclusions  Cajaninstilbene acid has antidepressant effects, which may be mediated by reducing serum corticosterone levels and regulating the levels of brain neurotransmitters.
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