Application of transcranial ultrasound-assisted thrombolysis in animal models of ischemic stroke
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(1. Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China.2. Department of Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041)

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Q95-33

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    Abstract:

    Transcranial ultrasound-assisted thrombolysis, also called sonothrombolysis (STL), is a method of treatment using ultrasound to promote clot dissolution and accelerate recanalization of occluded vessels in the brain with ischemic stroke. It has been demonstrated that STL can enhance the rate of thrombolysis without increasing complications such as symptomatic intracranial hemorrhage. Sonothrombolysis has been used in clinical trials for more than a decade, but has yet to be widely accepted. One of the main reasons is the lack of systematic and rigorous assessment of the safety and effectiveness of this approach. In this review, we summarize STL studies performed in animal models of ischemic stroke reported during the last 10 years and highlight some current issues and potential solutions.

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History
  • Received:April 18,2018
  • Revised:
  • Adopted:
  • Online: January 03,2019
  • Published: