Objective To investigate a method for systematically evaluating a precocious puberty rat model with phlegm-dampness syndrome. Methods To observe the symptoms of female SD rats in five groups, a precocious puberty with phlegm-dampness group, a precocious puberty without phlegm-dampness group, a blank control group, a parental model group, and a parental control group, and to conduct an open-field test to explore method for systematically evaluating animal model with the disease. Results There was no significant difference in body weight gain between the parental model group and the control group ( P >0. 05). Body weight in the 4-week-old female offsprings of the precocious puberty with phlegm-dampness group was significantly lower than that in the blank control group ( P < 0. 05). The weight of the precocious puberty with phlegm-dampness group was also decreased than the precocious puberty without phlegm-dampness group ( P < 0. 05). Compared with the parental control group, the female SD rats in the parental model group had a distinctly smaller total distance and speed of motion ( P < 0. 05). The motionless frequency and motionless time were clearly higher in the parental model group than in the parental control group ( P < 0. 05), but there was no significant difference ( P >0. 05) in the groups of young rats. Conclusions A high-fat diet failed to increase body weight in female SD rats; therefore, body weight index may not be a key indicator for systematic evaluation of animal models of phlegmdampness syndrome. The change of ethology in the rat model of phlegm-dampness syndrome is similar to the clinical manifestation of this syndrome. The open-field test can be used to further evaluate the animal model of phlegm-dampness syndrome. Difference in behavior was not found among female offsprings. The precocious puberty with phlegm-dampness syndrome remains to be futher investigated.