Myocardial contrast visual assessment of microcirculation after acute myocardial infarction in rabbits
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(1. Yunnan Second People’s Hospital, Kunming 650041,China. 2. Shanghai Sixth People’s Hospital, Shanghai 200030)

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Q95-33

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    Abstract:

    Objective In a rabbit model of acute myocardial infarction, blood perfusion of the infarction segment after acute myocardial infarction was subjected to myocardial acoustic contrast visual evaluation. Methods Twenty cleangrade Japanese rabbits were randomly assigned to an acute myocardial infarction model group (group A) and a sham operation control group (group S). Preoperative and 10- and 45-min postoperative electrocardiograms (ECGs) were collected, and routine ultrasound and ultrasonic imaging were performed at 20 min, 2 h, and 6 h before and after the operation. Blood perfusion in the molding segment after acute myocardial infarction was comprehensively evaluated. At the end of the experiment, the myocardial tissue of the molding section was excised for pathological examination. Results Conventional echocardiography showed significant changes in the magnitude of the motion of the modular segment at different time points after ischemia, and significant changes in cardiac histology, indicating the successful establishment of the acute myocardial infarction model in Japanese rabbits. At the same time, visual evaluation of myocardial contrast sonography showed that the myocardial blood volume and perfusion speed of group A were significantly lower than those of the noninfarcted segments and the corresponding segments of group S, which was consistent with the result of routine echocardiography and pathological histology. Conclusion Visual evaluation of myocardial sonography can accurately determine the status of blood perfusion in the myocardial segment after acute myocardial infarction, which is an effective diagnostic method.

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History
  • Received:April 12,2018
  • Revised:
  • Adopted:
  • Online: January 03,2019
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