Research progress of the application of iodoacetamide in animal models of digestive diseases
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(1. Guangxi University of Traditional Chinese Medicine, Nanning 530000, China. 2. First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000)

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Q95-33

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    Abstract:

    Iodoacetomide is the alkylation reagent of cysteine and histidine in proteomics, it can inhibit protease vigor and even disappear without protein degeneration, induce cell hypoxia, mucosal injury, anxiety and depression, can basically simulate digestive system diseases such as chronic gastritis, functional dyspepsia, ulcerative colitis pathophysiological mechanism. So it is widely used in the establishment and research of the animal models of chronic gastritis, functional dyspepsia and ulcerative colitis. In this paper, the mechanism and modeling method of the animal models of digestive system diseases are summarized as follows.

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History
  • Received:February 06,2018
  • Revised:
  • Adopted:
  • Online: September 12,2018
  • Published: