Research progress of the application of iodoacetamide in animal models of digestive diseases
Received:February 06, 2018  
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DOI:10.3969/j. issn. 1005 - 4847. 2018. 04. 021
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李建锋 广西中医药大学研究生学院,南宁
谢胜 广西中医药大学第一附属医院消化内科,南宁
陈广文 广西中医药大学第一附属医院消化内科,南宁
刘礼剑 广西中医药大学第一附属医院消化内科,南宁
黄晓燕 广西中医药大学第一附属医院消化内科,南宁
杨成宁 广西中医药大学第一附属医院消化内科,南宁
李娟 广西中医药大学研究生学院,南宁
谢洁如 广西中医药大学第一附属医院消化内科,南宁
戴文杰 广西中医药大学研究生学院,南宁
陈明冰 广西中医药大学研究生学院,南宁
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Abstract:
      Iodoacetomide is the alkylation reagent of cysteine and histidine in proteomics, it can inhibit protease vigor and even disappear without protein degeneration, induce cell hypoxia, mucosal injury, anxiety and depression, can basically simulate digestive system diseases such as chronic gastritis, functional dyspepsia, ulcerative colitis pathophysiological mechanism. So it is widely used in the establishment and research of the animal models of chronic gastritis, functional dyspepsia and ulcerative colitis. In this paper, the mechanism and modeling method of the animal models of digestive system diseases are summarized as follows.
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