Research progress on establishment of animal models of ovarian cancer
Received:August 30, 2017  
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DOI:10.3969/j. issn. 1005 -4847. 2018. 02. 021
KeyWord:ovarian cancer; animal model; preparation method; progress
              
AuthorInstitution
李冬冬 上海市杨浦区市东医院妇科,上海
王莉 上海市杨浦区市东医院妇科,上海
钟洁 上海市杨浦区市东医院妇科,上海
凌晨祁 上海市杨浦区市东医院妇科,上海
梁延平 上海市杨浦区市东医院妇科,上海
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Abstract:
      Ovarian cancer is the fifth leading cause of cancer?related death in women. 75% of ovarian cancer patients were detected at an advanced stage. At present, the disease lacks effective early screening method and the clinical therapy effect is poor, which has become a serious threat to women’s health. The use of animal models of ovarian cancer is an important mean to elucidate the pathogenesis of the disease, and to screen effective diagnosis and treatment. The disease models are mainly divided into four types: spontaneous, induced, transplanted and gene intervention type. Mice, rats, hens, Mirotus Fortis and Mongolian gerbil are mainly selected to prepare animal models of ovarian cancer. Based on recent literature reports, we reviewed the preparation method of animal models of ovarian cancer and introduced the evaluation standards and main characteristics of these animal models.
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