Research progress on highly active anti-retroviral therapy induced secondary osteoporosis
Received:October 18, 2017  
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DOI:10.3969/j. issn. 1005 -4847. 2018. 02. 017
KeyWord:highly active anti-retroviral therapy, HAART; osteoporosis; human immunodeficiency virus, HIV; mechanism
           
AuthorInstitution
刘浩 1. 北京大学口腔医学院·口腔医院, 北京 ; 2. 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,北京
李玮 北京大学口腔医学院·口腔医院, 北京
魏强 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,北京
周永胜 北京大学口腔医学院·口腔医院, 北京
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Abstract:
      Highly active anti-retroviral therapy (HAART) is a principal therapy method for AIDS. However, HAART is also one of crucial factors inducing bone mass loss and osteoporosis but its related mechanisms are obscure. Of note, nucleotide reverse transcriptase inhibitor (NRTI) and protease inhibitors (PI) may play key roles in inducing osteoporosis. This review summarizes the research progress in epidemiology and associated mechanisms on osteoporosis induced by NRTI and PI.
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