Effect of noise pollution on serum hormone and Hsp-70 levels in rats
Received:September 05, 2017  
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DOI:10.3969/j. issn. 1005 -4847. 2018. 02. 015
KeyWord:noise pollution; hormone; heat shock protein-70; Wistar rat
俞发荣 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
郭蕴萱 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
连秀珍 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
谢明仁 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
李登楼 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
陈望军 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
杨博 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
张诗爽 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州
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      Objective To study the effect of noise pollution on serum hormone and heat shock protein-70 (Hsp-70) levels in rats. Methods Forty male Wistar rats were randomly divided into control group (normal), experimental group (further divided into 35, 65 and 85 dB three groups), each group 10 animals, stimulated for 30 min once a day, continually stimulated for consecutive 20 days. On the 21st day of experiment, the serum noradrenaline (NA), testosterone (T), dopamine (DA) and Hsp-70 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results < /b> Compared with the control group, the body weight of experimental group (35, 65 and 85 dB groups) was reduced by 23.45%, 30.13%, and 35.64%, respectively The serum T and DA levels were decreased by 9.12%, 20.06%, 37.99% and 15.49%, 8.31%, 24.88%, respectively; while the serum NA and Hsp-70 levels were increased by 35.08%, 171.52%, 197.86%, and 39.34%, 195.09%, and 285.25%, respectively. All the result showed a significant difference ( P <0.01). Conclusions Noise pollution can significantly affect the serum levels of hormone and heat shock protein-70 expression in rats.
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