Effect of noise pollution on serum hormone and Hsp-70 levels in rats
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(Gansu Institute of Political Science and Law, Key Laboratory of Evidence Science and Technology Research and Application, Lanzhou 730070, China)

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Gansu Province Basic Research Innovation Groups Projects(No. 145RJIA333), Gansu University Science and Technology Innovation Team Project(No. 2016C -09), Lanzhou Talent Innovation and Entrepreneurship Project (No. 2016-RC -85)

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    Abstract:

    Objective To study the effect of noise pollution on serum hormone and heat shock protein-70 (Hsp-70) levels in rats. Methods Forty male Wistar rats were randomly divided into control group (normal), experimental group (further divided into 35, 65 and 85 dB three groups), each group 10 animals, stimulated for 30 min once a day, continually stimulated for consecutive 20 days. On the 21st day of experiment, the serum noradrenaline (NA), testosterone (T), dopamine (DA) and Hsp-70 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results < /b> Compared with the control group, the body weight of experimental group (35, 65 and 85 dB groups) was reduced by 23.45%, 30.13%, and 35.64%, respectively The serum T and DA levels were decreased by 9.12%, 20.06%, 37.99% and 15.49%, 8.31%, 24.88%, respectively; while the serum NA and Hsp-70 levels were increased by 35.08%, 171.52%, 197.86%, and 39.34%, 195.09%, and 285.25%, respectively. All the result showed a significant difference ( P <0.01). Conclusions Noise pollution can significantly affect the serum levels of hormone and heat shock protein-70 expression in rats.

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History
  • Received:September 05,2017
  • Revised:
  • Adopted:
  • Online: May 14,2018
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