PM2.5 induces oxidative stress and histopathological changes in the uterus of rats
Received:May 04, 2017  
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KeyWord:PM2.5;Rat;Uterus;Oxidative stress;Histopathology
张丰泉 新乡医学院公共卫生学院新乡市大气污染健康效应与干预重点实验室,新乡
董恩恒 新乡医学院公共卫生学院新乡市大气污染健康效应与干预重点实验室,新乡
王建强 新乡医学院第三附属医院病理科,新乡
曹锦程 新乡医学院公共卫生学院新乡市大气污染健康效应与干预重点实验室,新乡
郭旭东 新乡医学院公共卫生学院新乡市大气污染健康效应与干预重点实验室,新乡
吴卫东 新乡医学院公共卫生学院新乡市大气污染健康效应与干预重点实验室,新乡
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      Objective The aim of this work was to study whether PM2.5 induces oxidative stress and histopathological changes in uterine tissue of rats. Methods Thirty 4-week-old female Sprague-Dawley rats were randomly divided into the control group (normal saline), the low dose of PM2.5 group (1.5 mg/kg) and the high dose of PM2.5 group (37.5 mg/kg). After exposed to PM2.5 for 10 days, the rats were sacrificed to examine the histopathological changes in uterine tissues using H&E staining. The contents of SOD, GSH, MDA and LDH were also determined in the uterine tissues.Results Compared with the control group, PM2.5 caused changes in the uterine structure, showing a thinner endometrial epithelium and reduction of stromal cells and blood vessels. The assessment of oxidative stress parameters showed that the levels of MDA and LDH in the high dose group were (6.53±1.24) nmol/mg prot and (265.62±24.65) U/g prot, significantly higher than those in the control group (P<0.05). Compared with the control group, the levels of SOD and GSH in the high dose and low dose groups were significantly decreased (P<0.05).Conclusions PM2.5 exposure can cause damages in the rat uterus by inducing oxidative stress.
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