Clinically, kidney-yang deficiency is one of the main TCM syndromes in patients with major depressive disorder. Warming yang and reinforcing kidney as a therapeutic measure for the treatment of depressive disorder has achieved good clinical curative effect. However, there are some problems on the study of kidney-yang deficiency depression. One of the reasons is that the establishment methods of depression animal model with kidney-yang deficiency are not unified. In order to provide reference and further improve the replication method of depression animal models with kidney-yang deficiency, we systematically collected and analyzed the experiment results published in the past 15 years about the depression animal model with kidney-yang deficiency induced by glucocorticoid hormone drugs and find out their similarities and differences.