Alzheimer's disease and PRNP mutational mouse models
Received:March 08, 2016  
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DOI:10.3969/j.issn.1005-4847.2016.05.019
KeyWord:Alzheimer's disease (AD);Prion protein encoding gene (PRNP);Gene mutation;Mouse model
        
AuthorInstitution
赵进 中国计量大学生命科学学院, 杭州
蔡兆伟 浙江中医药大学动物实验研究中心, 杭州
管峰 中国计量大学生命科学学院, 杭州
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Abstract:
      Alzheimer's disease (AD) is one of the most common dementia of neurodegenerative disorders, which results from the deposition of amyloid-beta (Aβ) and there are no curative treatments for this disease at present. It had been proved that prion protein is the receptor for Aβ and it plays a key role in the progress of AD with dual-side effects. Prion protein can not only transfer neurotoxicity to neurons but also protect them from neurotoxicity of Aβ. The polymorphisms of prion protein encoding gene (PRNP) affect the AD incubation period and clinical symptoms in humans and other animals. The discovery of PRNP mutational mouse fills the gaps of existing AD mouse models in this research area, which is potential for the studies of pathogenesis, new drugs design and testing aspects. The role and effects of prion protein in AD pathogenesis were summarized in this paper, furthermore, the discovery and utility of PRNP gene mutational mouse in research on AD and/or amyloid diseases were reviewed, and in order to provide some guidance for AD animal model study.
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