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| Progress in research on the role of microRNA-424 in carcinogenesis and its related mechanism |
| Received:March 09, 2016 |
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| DOI：10.3969/j.issn.1005-4847.2016.05.017 |
| KeyWord:miR-424;Neoplasms;Leukemia |
| Author | Institution |
| 刘萍 |
首都医科大学宣武医院神经内科, 北京 |
| 赵海苹 |
首都医科大学宣武医院脑血管病研究室, 北京 |
| 罗玉敏 |
首都医科大学宣武医院神经内科, 北京 ;首都医科大学宣武医院脑血管病研究室, 北京 |
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| Abstract: |
| A member of miR-16 family, miR-424 has been found to be closely related with tumorigenesis, tumor progrssion, prognosis and therapy. This article reviews the expression changes, roles and possible regulating mechanisms of miR-424 in leukemia and various tumors such as breast, cervical, lung, liver and colorectal cancers. Recent studies have demonstrated that the expression of miR-424 is affected by many factors, and miR-424 could be a biomarker of diagnosis, staging and prognosis in cancers,to identify the area of tumor, and be a target of therapy. |
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