A brief review on the progress of mouse models of liver cancer
Received:November 13, 2015  
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DOI:10.3969/j.issn.1005-4847.2016.02.020
KeyWord:Liver cancer;Genetical modification;Mouse model
              
AuthorInstitution
李顺 上海市公共卫生临床中心, 上海
陈丽香 上海市公共卫生临床中心, 上海
彭秀华 上海市公共卫生临床中心, 上海
诸蒋鸣 苏州大学基础医学与生物科学学院, 江苏
周晓辉 上海市公共卫生临床中心, 上海
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Abstract:
      Liver cancer remains one of the leading cause of cancer death in the world. Animal models, especially mouse models, are important tools for studying the biological characteristics, pathogenesis, new drug screening and therapy of liver cancer. Up to now, although the development of various animal models accelerates the research of liver cancer, all the existing models have their own disadvantages. Lacking of economical and applicable animal models that can mimic the human liver cancer seriously restrict the further study of liver cancer. With the development of genetically modified technologies, it provides a fast, easy and reliable method to establish liver cancer models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field, which may open an avenue for functional cancer genomics and generation of liver cancer models by using gene editing technologies.
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