Research progress on animal models of depression and their evaluation methods
Received:October 14, 2014  
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DOI:10.3969/j.issn.1005-4847.2015.03.019
KeyWord:Depression;Animal model;Behavior;Biochemical criteria;Evaluation methods
           
AuthorInstitution
薛涛 泸州医学院, 四川泸州,
邬丽莎 泸州医学院, 四川泸州,
刘新民 中国医学科学院北京协和医学院药用植物研究所, 北京
王琼 泸州医学院, 四川泸州,
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Abstract:
      Depression, a seriously harmful disease to peoples' physical and mental health, is prevailing worldwide. But the etiology and pathological mechanism is still not fully uncovered. With the development of social economy and the pace of life speeding up, increasing pressure and vulnerable emotion cause depression incidence increased rapidly. For the further research on depression, study of depression mechanism and antidepressant drugs highly depends on effective animal models. The degree of similarity of animal models to human disease status and the accuracy and reliability of evaluation methods of animal models directly influence the value of the resuts of experiments. In this article we introduce the commonly used animal models of depression, the evaluation indicators at organism, organ, and molecular levels, and to provide theoretical references for the further studies on depression.
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