Research progress on animal models of depression and their evaluation methods
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    Abstract:

    Depression, a seriously harmful disease to peoples' physical and mental health, is prevailing worldwide. But the etiology and pathological mechanism is still not fully uncovered. With the development of social economy and the pace of life speeding up, increasing pressure and vulnerable emotion cause depression incidence increased rapidly. For the further research on depression, study of depression mechanism and antidepressant drugs highly depends on effective animal models. The degree of similarity of animal models to human disease status and the accuracy and reliability of evaluation methods of animal models directly influence the value of the resuts of experiments. In this article we introduce the commonly used animal models of depression, the evaluation indicators at organism, organ, and molecular levels, and to provide theoretical references for the further studies on depression.

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History
  • Received:October 14,2014
  • Revised:
  • Adopted:
  • Online: June 30,2015
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