Effect of the traditional Chinese medicine Bushen Gujin prescription on the expression of interleukin-1 and tumor necrosis factor-α in rabbit models of knee osteoarthritis
Received:January 20, 2015  
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DOI:10.3969/j.issn.1005-4847.2015.03.017
KeyWord:Bushen Gujin prescription;Rabbit;Knee osteoarthritis;Meloxicam;Chondrocytes;Interleukin-1;Tumor necrosis factor-α;Synovial fluid;Therapy
                       
AuthorInstitution
张冲 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
王恒树 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
阚秀莲 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
李健 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
郭梅 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
祁永玲 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
韩艳丽 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
杨瑞成 河北省中医院骨三科, 河北医科大学第二医院, 石家庄
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Abstract:
      Objective To explore the effect of traditional Chinese medicine (TCM) Bushen Gujin prescription on the expression of interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in the serum and synovial fluid of rabbit models of knee osteoarthritis. Methods Seventy-six healthy 8-month old male SPF New Zealand white rabbits were randomly divided into normal, model, western medicine (meloxicam) and TCM groups (n = 19 in each group). The rabbit models of knee osteoarthritis were generated by Hurth procedure, and were given respective drug treatment for consecutive 8 weeks. The expression of IL-1 and TNF-α in serum and synovial fluid was detected by ELISA assay. Results All the experimental rabbits showed narrowed knee articular space, rough articular cartridge surface, and obvious bone spur formation. The width of articular space of the meloxicam-treated rabbit models was between those of the model group and Chinese medicine-treated group. The expression of IL-1 and TNF-α in the serum and synovial fluid was increased in the rabbits of model groups, decreased in the two drug-treated groups (both P<0.01), but not significantly different between the two drug-treated groups (P>0.01). Conclusions The traditional Chinese medicine Bushen Gujin prescription can effectively inhibit synovial inflammation and reduce the expression of IL-1 and TNF- in the serum and synovial fluid. Our results provide experimental support for the use of this Chinese medicine in the treatment of knee osteoarthritis in clinics.
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