Effect of refraction and axial length on retinal nerve fiber layer thickness and optic disc morphology in guinea pigs
Received:January 07, 2005  
View Full Text  View/Add Comment  Download reader
DOI:10.3969/j.issn.1005-4847.2015.03.012
KeyWord:Guinea pig;Retinal nerve fiber layer thickness;Optic disc morphology;Optical coherence tomography
           
AuthorInstitution
李涛 复旦大学附属金山医院, 上海
周晓东 复旦大学附属金山医院, 上海
江瀚然 复旦大学附属金山医院, 上海
朱杰 复旦大学附属金山医院, 上海
Hits: 1398
Download times: 894
Abstract:
      Objective To observe the retinal nerve fiber layer (RNFL) thickness and optic disc morphology in guinea pigs by optical coherence tomography (OCT), and to investigate the correlation of spherical equivalent and axial length with those parameters. Methods Twenty healthy guinea pigs were used in this study. Spherical equivalent and axial length of nine guinea pigs were measured, and retinal nerve fiber layer thickness and optic disc morphology in the guinea pigs were analyzed by OCT. Results Spherical equivalent of the guinea pigs was positively correlated with average RNFL thickness, and with superior, temporal, inferior and nasal RNFL thicknesses; while ocular axial length was negatively correlated with average RNFL thickness, and with superior, temporal, inferior and nasal RNFL thicknesses. Spherical equivalent and axial length did not correlate significantly with disc edge area, optic disc area, average cup disc ratio, or cup volume. Vertical cup disc ratio significantly correlated with axial length, but did not with spherical equivalent. Conclusions The retinal nerve fiber layer thickness in guinea pigs is affected by both spherical equivalent and axial length. When guinea pigs are used as an animal model of glaucoma, the effect of refractive state and axial length should be considered.
Close
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=FF4EC6B96077DFE75FDA8CA0EDD581B558AFF095E9EEF1EC56712AB8C5A27BE3111DB18740E034F7EF54ABA3FA645EA6A070BD0557D38260BA010189D7143770CB3AECFDF2C52869770144C2776A91E56EED3B97B53EFFD7C8A58B50D161AE9F5864BD74602CB2C8BCABD100E0BE1DBD1218A03156F8CD19&pcid=&cid=&jid=&yid=FFD10F7019FAA9EC&aid=&vid=&iid=38B194292C032A66&sid=B8F8200D88DDC7D6&eid=211C7E02AC474301&fileno=20150312&flag=1&is_more=0"> var my_pcid=""; var my_cid=""; var my_jid=""; var my_yid="FFD10F7019FAA9EC"; var my_aid="";