Detection of growth phenotype and blood biochemical parameters of wild type-derived chromosome 1 substitution mouse strain
Received:December 08, 2014  
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DOI:10.3969/j.issn.1005-4847.2015.03.003
KeyWord:Inbred mice;Wild mice;Growth curve;Blood biochemical indexes;Organ coefficient;Chromosome 1 substitution mouse strain
                          
AuthorInstitution
高遄 东华大学化学化工与生物工程学院, 上海
徐伟 东华大学化学化工与生物工程学院, 上海
徐福意 东华大学化学化工与生物工程学院, 上海
张耀奇 东华大学化学化工与生物工程学院, 上海
赵莹 上海实验动物研究中心, 上海
赵丽亚 上海实验动物研究中心, 上海
周宇荀 东华大学化学化工与生物工程学院, 上海
李凯 东华大学化学化工与生物工程学院, 上海
肖君华 东华大学化学化工与生物工程学院, 上海
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Abstract:
      Objective To analyze the growth phenotype and blood biochemical parameters of chromosome 1 substitution mouse strain(CSS1), and investigate their potential of QTL mapping. Methods Body weight, body length, tail length, organ weight of the CCS1 mice were measured at different days to create a growth curve while blood biochemical indexes were measured at about the 80th day. Results The CCS1 mice were different from C57BL/6 mice in several indexes. Compared with the C57BL/6 mice during different developmental stages, six strains including B6-Chr1KM mice were significantly different in body weight. There were five strains including B6-Chr1CM mice significantly different with C57BL/6 mice in body length, and all of the CSS1 mice were significantly different from C57BL/6 mice in tail length. Part of CCS1 mice were significantly different from C57BL/6 mice in the weight of liver, spleen, kidney and brain. The ALT of female B6-Chr1CM mice was significantly higher than that in the C57BL/6 mice. The ALP of female B6-Chr1HZ mice was significantly higher than that in the male C57BL/6 and B6-Chr1KM mice, and was significantly lower than that in the C57BL/6 mice. The TB of male B6-Chr1CM, B6-Chr1SMX and B6-Chr1HZ mice was significantly higher than that of the C57BL/6 mice. The TG of male B6-Chr1SMX mice and male B6-Chr1TW mice was significantly higher than that in the C57BL/6 mice. Conclusions The phenotype of Chr1 CSS mice is quite different from commonly used inbred strain C57BL/6 mice. CCS1 mice show great potential in QTL mapping for their characteristic growth phenotype and blood biochemical indexes.
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