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| Detection of growth phenotype and blood biochemical parameters of wild type-derived chromosome 1 substitution mouse strain |
| Received:December 08, 2014 |
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| DOI：10.3969/j.issn.1005-4847.2015.03.003 |
| KeyWord:Inbred mice;Wild mice;Growth curve;Blood biochemical indexes;Organ coefficient;Chromosome 1 substitution mouse strain |
| Author | Institution |
| 高遄 |
东华大学化学化工与生物工程学院, 上海 |
| 徐伟 |
东华大学化学化工与生物工程学院, 上海 |
| 徐福意 |
东华大学化学化工与生物工程学院, 上海 |
| 张耀奇 |
东华大学化学化工与生物工程学院, 上海 |
| 赵莹 |
上海实验动物研究中心, 上海 |
| 赵丽亚 |
上海实验动物研究中心, 上海 |
| 周宇荀 |
东华大学化学化工与生物工程学院, 上海 |
| 李凯 |
东华大学化学化工与生物工程学院, 上海 |
| 肖君华 |
东华大学化学化工与生物工程学院, 上海 |
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| Abstract: |
| Objective To analyze the growth phenotype and blood biochemical parameters of chromosome 1 substitution mouse strain(CSS1), and investigate their potential of QTL mapping. Methods Body weight, body length, tail length, organ weight of the CCS1 mice were measured at different days to create a growth curve while blood biochemical indexes were measured at about the 80th day. Results The CCS1 mice were different from C57BL/6 mice in several indexes. Compared with the C57BL/6 mice during different developmental stages, six strains including B6-Chr1KM mice were significantly different in body weight. There were five strains including B6-Chr1CM mice significantly different with C57BL/6 mice in body length, and all of the CSS1 mice were significantly different from C57BL/6 mice in tail length. Part of CCS1 mice were significantly different from C57BL/6 mice in the weight of liver, spleen, kidney and brain. The ALT of female B6-Chr1CM mice was significantly higher than that in the C57BL/6 mice. The ALP of female B6-Chr1HZ mice was significantly higher than that in the male C57BL/6 and B6-Chr1KM mice, and was significantly lower than that in the C57BL/6 mice. The TB of male B6-Chr1CM, B6-Chr1SMX and B6-Chr1HZ mice was significantly higher than that of the C57BL/6 mice. The TG of male B6-Chr1SMX mice and male B6-Chr1TW mice was significantly higher than that in the C57BL/6 mice. Conclusions The phenotype of Chr1 CSS mice is quite different from commonly used inbred strain C57BL/6 mice. CCS1 mice show great potential in QTL mapping for their characteristic growth phenotype and blood biochemical indexes. |
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