Effects of angiotensin II blockade on renal blood flow and renal oxygen consumption in chronic renal failure rats
Received:March 18, 2014  
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KeyWord:Angiotensin II blockade;Renal blood flow;Renal oxygen consumption;Chronic renal failure;Rats
祝婷婷 上海中医药大学附属曙光医院肾病科, 上海市教委创新团队, 上海市中医重点实验室, 上海
范德生 上海中医药大学附属曙光医院病理科, 上海
杨婧 上海中医药大学附属曙光医院肾病科, 上海市教委创新团队, 上海市中医重点实验室, 上海
周珊珊 上海中医药大学附属曙光医院肾病科, 上海市教委创新团队, 上海市中医重点实验室, 上海
王琛 上海中医药大学附属曙光医院肾病科, 上海市教委创新团队, 上海市中医重点实验室, 上海
严睿峻 上海中医药大学附属曙光医院肾病科, 上海市教委创新团队, 上海市中医重点实验室, 上海
何立群 上海中医药大学附属曙光医院肾病科, 上海市教委创新团队, 上海市中医重点实验室, 上海
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      Objective To observe the effects of angiotensin Ⅱ(Ang Ⅱ)blockade on renal function, renal blood flow and renal oxygen consumption in chronic renal failure (CRF) rats induced by 5/6th kidney ablation /infarction (5/6A/I). Methods Sprague-Dawley rats were randomly divided into 3 groups: the normal group (group A, n =14), model group (group B, n=14) and angiotensin II blockade (Cozaar with Monopril) treatment group (group C, n =14). The chronic renal failure (CRF) rat models were induced by 5/6th kidney ablation/infarction. The tail artery systolic pressure (SBP), diastolic blood pressure (DBP) and tail vein serum creatinine (Scr), blood urea nitrogen (BUN), hemoglobin (Hb) and creatinine clearance rate (Ccr) were assessed before and after intervention. The course of treatment was sixty days. The renal blood flow (RBF), blood gas analysis of abdominal aortic and renal vein, left renal vein pressure (RVpO2) were detected and remnant renal oxygen consumption (QO2 /TNa) was calculated, and the pathological changes of remnant kidney were observed after the 60 d intervention. Results (1) Compared with the group A, the levels of Scr, BUN and tail artery SBP, DBP were significantly increased (P<0.01 for all), and the levels of Ccr and Hb were significantly decreased (P<0.01) in the groups B and C, demonstrating the successful modeling. (2) Compared with the group B, the levels of Scr, tail artery SBP, DBP and QO2/TNa were significantly decreased (P<0.01 for all), the levels of BUN were decreased (P<0.05), the levels of Hb, Ccr and RVpO2 were significantly increased (P<0.01 for all), the level of RBF was increased (P<0.05) in the group C after intervention.(3) The histopathological examination of the remnant renal tissue showed that the pathological changes in the group C were apparently reduced, better than those of the Group B. Conclusions Angiotensin II blockade can increase RBF, reduce renal oxygen consumption, improve renal function, and reduce the renal pathological changes in CRF rats. The mechanism of renal protection may be related to the regulation of cellular energy metabolism and improvement of renal oxygen consumption.
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