Abstract:The establishment of rat models of type 2 diabetes mellitus can provide an ideal animal experimental technology platform for the research of pathogenesis, prevention, diagnosis and treatment of diabetes mellitus and its complications. The establishment of type 2 diabetic rat models may be affected by various factors. In this paper, the main factors, streptozotocin (STZ) application, high fat and calorie diet, selection and breeding of rats are reviewed, which will provide an important reference for the development of rat models type 2 diabetes.