Effect of traditional Chinese medicine composit Guben Yiliu Ⅲ combined with gemcitabine on human pancreatic cancer xenograft in nude mice
Received:April 15, 2014  
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DOI:10.3969/j.issn.1005-4847.2014.03.020
KeyWord:Pancreatic cancer;Integrated treatment of traditional Chinese medicine and Western medicine;Nude mouse xenograft;Gemcitabine;Guben Yiliu Ⅲ
                    
AuthorInstitution
刘炬 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 防癌科, 北京
钱海利 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 分子肿瘤学国家重点实验室, 北京
徐志坚 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 防癌科, 北京
张立生 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 分子肿瘤学国家重点实验室, 北京
叶霈智 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 中医科, 北京
田爱平 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 中医科, 北京
杨宏丽 中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 中医科, 北京
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Abstract:
      Objective To explore whether the Chinese medicine Guben Yiliu Ⅲ can improve the effect of gemcitabine on human pancreatic cancer xenograft in nude mice. Methods Nude mice with transplanted human pancreatic cancer were divided randomly into 4 groups: control group, gemcitabine treatment group, combined (Guben Yiliu Ⅲ + gemcitabine) group, and Guben Yiliu Ⅲ group, 10 mice in each group. The gemcitabine group and combined group were treated with gemcitabine from the 8th day after transplantation in a dose of 100 mg/kg by i.p. injection, twice a week. Guben Yiliu Ⅲ and combined groups were given the aqueous solution of Guben Yiliu Ⅲ granules p.o. since the 8th day after transplantation. Result The inhibition rate of transplanted tumor in the three treatment groups were 48.9% in the gemcitabine group, 68.9% in the combined group, and 28.0% in the Guben Yiliu Ⅲ group. The combined group showed a significantly higher inhibition rate than the gemcitabine group (P<0.05). The gemcitabine group, combined group and Guben Yiliu Ⅲ group showed a significantly slower growth rate than the control group. However, the combined treatment group showed a pronounced side effect and body weight loss than the other 3 groups. Conclusions The Chinese medicine Guben Yiliu Ⅲ can improve the inhibitory effect of gemcitabine on nude mice with human pancreatic cancer xenograft in the auxilla of nude mice.
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