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| Effect of traditional Chinese medicine composit Guben Yiliu Ⅲ combined with gemcitabine on human pancreatic cancer xenograft in nude mice |
| Received:April 15, 2014 |
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| DOI：10.3969/j.issn.1005-4847.2014.03.020 |
| KeyWord:Pancreatic cancer;Integrated treatment of traditional Chinese medicine and Western medicine;Nude mouse xenograft;Gemcitabine;Guben Yiliu Ⅲ |
| Author | Institution |
| 刘炬 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 防癌科, 北京 |
| 钱海利 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 分子肿瘤学国家重点实验室, 北京 |
| 徐志坚 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 防癌科, 北京 |
| 张立生 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 分子肿瘤学国家重点实验室, 北京 |
| 叶霈智 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 中医科, 北京 |
| 田爱平 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 中医科, 北京 |
| 杨宏丽 |
中国医学科学院北京协和医学院 肿瘤医院, 肿瘤研究所, 中医科, 北京 |
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| Abstract: |
| Objective To explore whether the Chinese medicine Guben Yiliu Ⅲ can improve the effect of gemcitabine on human pancreatic cancer xenograft in nude mice. Methods Nude mice with transplanted human pancreatic cancer were divided randomly into 4 groups: control group, gemcitabine treatment group, combined (Guben Yiliu Ⅲ + gemcitabine) group, and Guben Yiliu Ⅲ group, 10 mice in each group. The gemcitabine group and combined group were treated with gemcitabine from the 8th day after transplantation in a dose of 100 mg/kg by i.p. injection, twice a week. Guben Yiliu Ⅲ and combined groups were given the aqueous solution of Guben Yiliu Ⅲ granules p.o. since the 8th day after transplantation. Result The inhibition rate of transplanted tumor in the three treatment groups were 48.9% in the gemcitabine group, 68.9% in the combined group, and 28.0% in the Guben Yiliu Ⅲ group. The combined group showed a significantly higher inhibition rate than the gemcitabine group (P<0.05). The gemcitabine group, combined group and Guben Yiliu Ⅲ group showed a significantly slower growth rate than the control group. However, the combined treatment group showed a pronounced side effect and body weight loss than the other 3 groups. Conclusions The Chinese medicine Guben Yiliu Ⅲ can improve the inhibitory effect of gemcitabine on nude mice with human pancreatic cancer xenograft in the auxilla of nude mice. |
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