Spontaneous neoplastic lesions of Wistar rats and their incidences
Received:September 23, 2013  
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DOI:10.3969/j.issn.1005-4847.2014.02.017
KeyWord:Wistar rat;Carcinogenicity study;Spontaneous neoplastic lesions
           
AuthorInstitution
徐艳峰 中国医学科学院医学实验动物研究所, 卫生部人类疾病比较医学重点实验室, 国家中医药管理局人类疾病动物模型三级实验室, 北京
侯粉霞 中国疾病预防控制中心职业卫生与中毒控制所, 北京
杨慧芳 中国疾病预防控制中心职业卫生与中毒控制所, 北京
徐玉环 中国医学科学院医学实验动物研究所, 卫生部人类疾病比较医学重点实验室, 国家中医药管理局人类疾病动物模型三级实验室, 北京
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Abstract:
      Objective To investigate the spontaneous neoplastic lesions and their incidences in rats. Methods Sixty male and 60 female specific pathogen-free Wistar rats (4-weeks old ) were used in this study. The rats were acclimated for 1 week prior to initiation of the experiment. They were fed with conventional feed for 104 weeks and then sacrificed for histopathological examination. Results Various neoplastic lesions of the rats and their incidences were analyzed and reported.For male rats, their total tumor incidence was 49.12%, the benign tumor incidence was 38.60% and the malignant tumor incidence was 17.54%. The benign neoplastic lesions mainly were pituitary adenoma (19.30%), testis Leydig cell tumor (5.26%) and subcutaneous fibroma (5.26%). The malignant neoplastic lesions mainly were squamous cell carcinoma (7.02%) and lymphoid hematopoietic system tumors (3.51%). For female rats, their total tumor incidence was 60.34%, the benign tumor incidence was 50.00% and the malignant tumor incidence was 15.52%. The benign neoplastic lesions mainly were breast fibroadenoma (25.86%) and pituitary adenoma (24.14%). The malignant neoplastic lesions mainly were adenocarcinoma (5.17%) and breast cancer (3.45%). Conclusions The spontaneous neoplastic lesions and their incidences reported in this paper provide another data of the spontaneous tumors of SPF Wistar rats and may provide some reference for relevant technical staffs.
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