Effects of chronic restraint stress on learning and memory in SD and Wistar rats
Received:October 18, 2013  
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KeyWord:Wistar rat;Sprague-Dawley rat;Restraint stress;Novel-object recognition test;Morris water maze test;Spatial memory;Working memory
王逸 中国医学科学院 北京协和医学院 药用植物研究所, 北京
卢聪 中国医学科学院 北京协和医学院 药用植物研究所, 北京
宋广青 中国医学科学院 北京协和医学院 药用植物研究所, 北京
陈怡西 泸州医学院, 泸州
武宏伟 中国医学科学院 北京协和医学院 药用植物研究所, 北京
王琼 中国医学科学院 北京协和医学院 药用植物研究所, 北京 ;泸州医学院, 泸州
曲丽娜 中国航天员科研训练中心航天医学基础与应用国家重点实验室, 北京
李莹辉 中国航天员科研训练中心航天医学基础与应用国家重点实验室, 北京
刘新民 中国医学科学院 北京协和医学院 药用植物研究所, 北京
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      Objective To investigate the effects of chronic restraint stress on learning and memory in Wistar and Sprague-Dawley (SD) rats. Methods Healthy adult male Wistar rats (n=6) and Sprague-Dawley rats (n=6) were subjected to restraint stress 10 h daily for 28 days. After that, all rats were tested for recognition memory by novel object recognition test, and spatial memory and working memory by Morris water maze test. Results After restraint for 10 h daily for 28 days, the restraint rats of the two strains demonstrated lower discrimination index(DI)than the control group, but only SD rats showed significant difference (P<0.05). The restraint SD rats showed higher escape latency than the control rats, and on the 5th day the difference became significant (P<0.05), and there was no significant difference between Wistar restraint and control rats. The working memory test showed that restraint SD rats exibited longer escape latency than the control rats (P<0.05), while Wistar rats didn't show significant difference between the two groups. Conclusions The results of this study demonstrate that the impairments of learning and memory in SD rats subjected to restraint 10 hour per day for 28 days are more serious than that in the Wistar rats. Therefore, SD rats may be a better choice as an animal model to study the effects of chronic restraint stress on learning and memory impairment.
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