Preliminary discussion on the effects of guanosine, curcumin on learning and memory in AD double transgenic mice
Received:October 12, 2013  
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DOI:10.3969/j.issn.1005-4847.2014.02.007
KeyWord:Guanosine;Curcumin;APPswe/PS1dE9 double transgenic mice;Ethology
                    
AuthorInstitution
樊惠 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
冯慧利 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
党惠子 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
陈晓培 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
任映 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
杨金铎 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
王蓬文 国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室; 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室, 北京
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Abstract:
      Objective Using Morris water maze test to evaluate the effects of guanosine and curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice. Methods 3-month old APPswe/PS1dE9 dtg mice were randomly divided into model group, donepezil HCL group, guanosine group, curcumin group, curcumin and guanosine group (n=12), with age-matched Wild C57BL/6J mice of the same genetic background as normal control group. Medication was given once a day for 1 month. Using Morris water maze to test the spatial learning and memory ability of mice. Results Guanosine and curcumin could improve spatial learning and memory disorders of AD mice, particularly in the group of curcumin.Conclusion Guanosine and curcumin improve the cognitive ability of APPswe/PS1dE9 double transgenic mice with early cognitive impairment.
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