Exploration of the establishment of a rat model of chronic diabetic skin ulcer simulating the traditional Chinese syndrome
Received:September 01, 2013  
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DOI:10.3969/j.issn.1005-4847.2014.01.012
KeyWord:Skin ulcer, model;Yin Syndrome;Diabetes mellitus;Rats
                 
AuthorInstitution
李媛 北京中医药大学, 北京
赵光明 北京中医药大学, 北京
董建勋 首都医科大学附属北京中医医院, 北京
路广林 北京中医药大学, 北京
张旭辉 北京中医药大学, 北京
王乐平 北京中医药大学, 北京
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Abstract:
      Objective To observe the effects of different modeling methods on the wound morphology and healing time of chronic skin ulcers in diabetic rats. Methods SD rats (n=50) were randomly divided into five groups, 10 rats in each group: skin defect group (group QS: dermal deficiency), diabetes group (group DM: STZ injection+skin excision), diabetes plus Staphylococcus aureus group (group DMJJ: STZ injection+skin excision+bacterial infection), diabetes plus hydrocortisone group (group DMJS: STZ injection+skin excision+hydrocortisone intervention) and diabetes plus hydrocortisone and implantation of foreign body group (DMYW group: STZ injection+skin excision+hydrocortisone intervention + foreign body embedded). The rats were measured for body weight and wound healing every day, and blood glucose after stable diabetes once a week. The rats were sacrificed 12 days later and the skin lesions were examined by histopathology.Results The healing rate of the DMYW group was significantly slower than that in the other groups (P<0.01). At 12 days after modeling, the healing rate of the DMYW group was significantly lower than that of the remaining groups (P<0.01), while the healing rates were not significantly different among the remaining groups.Conclusions The modeling method of DMYW group can show skin wounds similar to the clinical characteristics of "Yin syndrome", and the addition of foreign body implantation significantly prolongs the rat skin healing time.
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