Effects of juglone on growth of human hepatocellular carcinoma BEL-7402 xenografts in nude mice
  
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KeyWord:Juglone;Human hepatocellular carcinoma;BEL-7402 cell line;Transplanted tumor;nude Mouse;Growth inhibition;Pharmacodynamics;
CHEN Li,ZHANG Jian,WANG Si-ying,HUANG De-wu,GU Wei-wang
CHEN Li1,ZHANG Jian2,WANG Si-ying1,HUANG De-wu1,GU Wei-wang2(1.Laboratory Animal Center,Anhui Medical University,Hefei 230032,China,2.Laboratory Animal Center & Department of Comparative Medicine,Southern Medical University,Guangzhou 510515)
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Abstract:
      Objective To evaluate the inhibitory effect and toxicity of juglone administered via different routes on the nude mice model bearing subcutaneously transplanted tumor.Methods Human hepatocellular carcinoma BEL-7402 cells were subcutaneously injected into nude mice.The resultant tumors were taken and prepared into small tissue blocks,which were implanted subcutaneously into nude mice to establish mouse models bearing human hepatoma.Juglone was administered at different doses by intraperitoneal injection and ...
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