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| MicroPET observation of the effect of curcumin on cerebral glucose metabolism in APPswe/PS1dE9 double transgenic mice |
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| DOI： |
| KeyWord:microPET;18F-FDG;Cerebral glucose metabolism;Curcumin;APPswe/PS1dE9 double transgenic mice; |
| WANG Hong,GAO Kai,LI Rui-sheng,REN Ying,ZHU Zhi-hui,SUN Hai-yun,YANG Jin-duo,WANG Peng-wen |
WANG Hong1,GAO Kai2,LI Rui-sheng1,REN Ying1,ZHU Zhi-hui1,SUN Hai-yun1,YANG Jin-duo1,WANG Peng-wen(1.Laboratory of Pharmacology of Traditional Chinese Medicine,Dongzhimen Hospital,BUCM,Beijing 100700,China,2.Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Comparative Medical Center,Peking Union Medical College,Beijing 100021,China)
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| Abstract: |
| Objective To observe the status of cerebral glucose metabolism in normal control group mice,APP/PS1 double transgenic mice of model group and curcumin treatment group by 18F-FDG microPET.Methods APP/PS1 dtg mice from the model group,curcumin treatment group,and normal C57BL/6J mice with the same background were randomly selected(age: 6 months;n=3)for microPET study.Each mouse was anesthetized using 2% isoflurane and was injected through a tail vein with 14.8-16.5 MBq 18F-FDG as a bolus.After 45-minute of 18... |
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