Effect of raldh2gene knock-down on the cardiac development in zebrafish
  
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DOI:
KeyWord:Retinal dehydrogenase type 2;Morpholino antisense oligonucleotides;Cardiac development;Zebrafish;
HOU Jia,GUI Yong-hao,WANG Yue-xiang,SONG Hou-yan
HOU Jia1,GUI Yong-hao1,WANG Yue-xiang2,SONG Hou-yan2
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Abstract:
      Objective To establish a model of retinal dehydrogenase type 2(raldh2) gene knock-down zebrafish embryos,and to explore the effect of insufficient retinoid acid(RA) signaling on the early embryonic cardiac development,especially on the regulation of cardiac development-related nppa and tbx20 gene expression.Methods A morpholino antisense oligonucleotides(MO) targeting zebrafish raldh2 gene was designed to knock down its expression and constructed a raldh2-EGFP plasmid to verify the effectiveness and specifi...
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