A mouse model of physiological cardiac hypertrophy induced by exercise-training on treadmill
  
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WANG Xiao-jian,WANG Ji-zheng,WANG Chang-xin,LIU Ji-bin,DONG Wei,ZHANG Lian-feng,HUI Ru-tai
WANG Xiao-jian1,WANG Ji-zheng1,WANG Chang-xin1,LIU Ji-bin1,DONG Wei2,ZHANG Lian-feng2,HUI Ru-tai1.(1.Key Laboratory of Clinical Cardiovascular Genetics,Ministry of Education(Sino-German Laboratory for Molecular Medicine)
,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China,2.Genetics Center,Institute of Laboratory Animal Science,Chinese Academy of Medical Science and Comparative Medical Center,Peking Union Medical College,Being 100021,China)
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Abstract:
      Objective To investigate whether exercise-training on a treadmill can induce physiological cardiac hypertrophy in mice,and to determine the difference between the physiological and pathological cardiac hypertrophy.Methods Forty wild-type male C57BL/6 mice were randomly divided into four groups(10 mice in each group): normal control,training group,sham control,and transverse aortic constriction(TAC) surgery group.After treadmill training for 40 days and at 2 weeks after TAC surgery,the heart function and str...
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