Abstract:Objective To establish a model of early atherosclerosis in guinea pig and explore its pathogenetic mechanisms,compared with the modeling in rats,and to clarify the characteristics and advantages of this guinea pig model of atherosclerosis.Methods The differences of early atherosclerosis induced by high lipid diets in guinea pig and rat were investigated.Aortic intima-media thickness,intimal inflammatory cells infiltration and plaque development were observed by pathology with HE staining.Serum lipid levels ...