Objective To establish and evaluate the feasibility of a rat model of chronic obstructive pulmonary dis-ease(COPD) induced by intratracheal instillation of lipopolysaccharide(LPS).Methods LPS or saline was instilled in-tratracheally in rats once a week for consecutive 8 weeks.The rats were anesthetized and taken for the measurement of lung resistance(RL) and dynamic compliance(Cdyn).Total and differential white blood cell counts in bronchoalveolar lavage fluid(BALF) were carried out.The pathological changes...