Establishment of a rat model of chronic obstructive pulmonary disease by intratracheal instillation of lipopolysaccharide
  
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KeyWord:Chronic obstructive pulmonary disease;Lipopolysaccharide;Rat;Model;
LIU Jun-bo,HUANG Meng-shan,YU Chen-xi,WANG Yan,TANG Fa-di
LIU Jun-bo,HUANG Meng-shan,YU Chen-xi,WANG Yan,TANG Fa-di(Zhejiang Research Laboratory of Respiratory Drugs,College of Medicine,Zhejiang University,Hangzhou 310058,China)
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Abstract:
      Objective To establish and evaluate the feasibility of a rat model of chronic obstructive pulmonary dis-ease(COPD) induced by intratracheal instillation of lipopolysaccharide(LPS).Methods LPS or saline was instilled in-tratracheally in rats once a week for consecutive 8 weeks.The rats were anesthetized and taken for the measurement of lung resistance(RL) and dynamic compliance(Cdyn).Total and differential white blood cell counts in bronchoalveolar lavage fluid(BALF) were carried out.The pathological changes...
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