Influence of Exo-1 gene on the chimerism rate in telomerase-defecient mice
  
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KeyWord:Telomerase gene dysfunction;Bone marrow transplantation;Hematopoietic stem cells(HSCs);Aging;Mice;
SHI Gui-ying,CHEN Xian-da,CHEN Zhi-ying,JU Zhen-yu
SHI Gui-ying,CHEN Xian-da,CHEN Zhi-ying,JU Zhen-yu(Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences & Comparative Medical Center,Peking Union Medical College,Beijing 100021,China)
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Abstract:
      Objective To investigate the influence of Exo-1 gene deletion on the engraftment of hematopoietic stem cell(HSC) transplantation by different methods into the telomerase knockout mice.Methods Bone marrow cells or KSL((c-kit +,Sca-1 +,lineage-) cells were isolated from CD45.1 mice,and then injected into recipients,which were telomer-ase gene knockout or Exo-1 and telomerase gene double knockout mice with or without irradiation.At 1 month later,pe-ripheral blood was collected and analyzed by flow cytometry.Re...
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