Objective To establish a mouse model of hypoxic pulmonary hypertension and to explore the expres-sion of proliferating cell nuclear antigen(PCNA) in aorta and pulmonary artery smooth muscle cells of rats with hypoxic pulmonary hypertension.Methods SPF SD mice were randomly divided into 2 groups: normal group(n = 10) and hypox-ia group(n = 10).The mouse model of hypoxic pulmonary hypertension was constructed by intermittent ordinary pressure hypoxia.Histology of HE stained lung tissue sections and image anal...