Abstract:Objective To establish an experimental model to study the stressralated changes of intestinal mucosa barrier(IMB) following serious traumatic brain injury(TBI) Methods Sixty-four healthy male Wistar rats were randomized into two groups.TBI model group(n=32) treated by TBI by Feeney's method,and control group(n=32)treated by sham operation.Each group was divided into four subgroups taken at 6 h,12 h,24 h,and 48 h after acute brain trauma(n=8,for each subgroup).The ileum tissue was carefully examed by light and electron microscopy.Results The intestinal mucosa was damaged and the intercellular space of intestinal mucosal epithelial cells was increased in TBI rats compared with that of control group.Conclusion This experimental model can be used to study the stress-related changes of IMB after serious TBI.