Arterial and Renal Complications in Rats with Type 2 Diabetes Mellitus
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R587.2;R-332

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    Abstract:

    Objective To establish a rat diabetic model closely resembling the metabolic abnormalities of human type 2 diabetes mellitus and observe its renal and arterial structural changes.Methods 8 weeks old SD rats were injected with low dose streptozotocin(STZ) after high-fat and high-sugar diet given for 4 weeks.The changes of vascular function and renal function indexes were assessed after 4 and 8 weeks,respectively,and the pathological changes of kidney and arteries were examined.Results The model group showed hyperglycemia,hyperlipidemia,insulin resistance,renal and vascular disfunctions.The renal pathological examination revealed hyperplasia of mesangial and endothelial cells,swelling of renal tubules,presence of numerous protein and cellular casts in the renal tubules,and a prominent leukomonocyte infiltration in the renal pelvic tissue.Loss or damages of endothelial cells and increase of the sub-endothelial space in the artery wall were observed by transmission electron microscopy.Conclusion A rat model of type 2 diabetes mellitus has been successfully established by using high fat and sugar diet and low dose STZ injection.Renal and vascular pathological changes occurred in the rats within 4 and 8 weeks after treatment.The established rat models provide an ideal basis for experimental studies on type 2 diabetes mellitus.

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  • Received:
  • Revised:December 02,2006
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