Exploration on the Conditions of Establishment of MPTP-Induced Mouce Model of Parkiuson''''s Disease
  Revised:October 10, 2006
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KeyWord:1-methyl-4-phenyl-1,2,3,6-Tetrahydropyridine,Tyrosine hydroxylase,Immunohistochemistry,Dopamine,Parkinson's disease
LIU Shu-min,ZHANG Lin,CONG Shu-yuan,YU Hai-long
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      Objective To observe the behavior and content of dopamine(DA)in striatum of mice treated with different doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),and to explore the optimal conditions of establishment of a mouse model of parkinson's disease.Methods C57BL mice were administered at different doses of MPTP.Pole test was conducted to determine the motor coordination and the content of DA in striatum in different groups of mice was determined by HPLC.Results All MPTP treated mice showed different disability in pole test and remarked decrease in content of TH and DA.Conclusion Symptoms of Parkinsonism in mice can be induced by MPTP administration.In this model,different dose of MPTP and different drug administration route should be used according to the goal of actual study.
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