Influence of Implantation of Autologous Endothelial Progenitor Cells (EPC)on Neoangiogenesis and Cardiac Function in Rats with acute Myocardial infarction
  Revised:May 29, 2006
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KeyWord:Endothelial progenitor Cells,Cell implantation,Myocardial contraction,Myocardial Ischemia
PAN Si-Lin,XING Quan-sheng,SUN Long,RONG You-bao,CAO Qian,JI Zhi-xian,WU Qin
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Abstract:
      Objective To explore the feasibility of local implantation of endothelial progenitor cells(EPC)from peripheral bloods to promote neoangiogenesis and restore contractility in ischemic myocardium.Methods 5 mL of peripheral blood was obtained from the femoral artery of Sprague-Dawley rats.Myocardial infarction was induced by ligating the left anterior descending coronary artery(LAD).Four weeks after ligation,autologous EPCs isolated from the peripheral blood of each rat were locally injected into the ischemic myocardium.In the control groups,cell culture medium was injected.Results Contractility of ischemic myocardium in the rats of EPC groups was significantly better than that in the control group.Simultaneously,much higher microvessel density(MVD)was observed in the EPC group.Conclusion Local implantation of autologous EPC improves post-ischemic myocardial contractility and resultantly cardiac function improves.Together with higher MVD,these favorable outcomes encourage future clinical trials of intramyocardial implantation of autologous EPCs in the treatment of chronic myocardial ischemia.
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