Objective Gout is a disease caused by hyperuricemia as a result of disturbance in purin metabolism and/or reduction of excreation of uric acid in the urine.Consequently,uric acid deposits in tissues.Presently,there has not been animal model of urarthritis similar to human gout.In this article the methodology,mechanisms and applications of current animal models of hyperuricemia and urarthritis were reviewed,their characteristics and drawbacks were analyzed,and prospective directions of animal models of hyperuricemia and urarthritis were discussed.