The SARS is a emerging infectious disease which was conformed in china firstly and spread over 37 countries and regions. Three SARS CoV animal models with Rhesus macaque, Lewis rat and Microtus brandtii were established in Institute of Laboratory Animal Science, CAMS and PUMC , China. In current paper, those SARS-CoV animal models were compared on pathological changes, immuno- response and the replication of SARS- CoV in vivo. 8 Rhesus macaques, 20 Microtus brandtii and 9 Lewis rats were infected with SARS-CoV through the nasal cavity, and sacrificed for collecting pathologic tissues on different day after inoculation. Similar pathological changes were observed in SARS CoV infected Rhesus macaques, Lewis rats and Microtus brandtii and the pathological changes was similar with SARS case of human. The SARS-CoV was carried and replicated in Rhesus macaques and last longer than Lewis rats. The infected Microtus brandtii carried SARS-CoV, but the replication of the virus was not detected by isolation and culture of the virus on Vero-E6 cell. The SARS-CoV specific IgG was detected in both of rhesus macaques and Lewis rats( The detective agents was not available for IgG of Microtus brandtii). It is interesting that SARS-CoV caused Microtus brandtii death at a rate of 10%, which is similar to the mortality of SARS on human. ON summary, the Rhesus macaques model is one of the ideal animal model to study SARS-CoV replication and vaccine and the Microtus brandtii can be used to study the lethality of SARS-CoV.